Fig. 8
From: NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells
Regulation of γc expression by NFAT1 and NFκB. Summary of the regulatory mechanism of γc expression by NFAT1 and NFκB in activated T cells. The binding of TCR to peptide-MHC leads to the dephosphorylation of NFAT1 and activation of NFκB. Activation of NFκB and NFAT1 translocated to the nucleus, where it induces γc expression. In the nucleus, NFAT1 physically binds to the -111 to -101 site and NFκB binds to the -114 to -99 site on the γc promoter region and positively regulate γc gene expression