You are viewing the site in preview mode

Skip to main content
Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Induction of LY6E regulates interleukin-1β production, potentially contributing to the immunopathogenesis of systemic lupus erythematosus

Fig. 1

Induction of LY6E in peripheral blood monocytes and kidney macrophages from SLE patients. CD14 + monocytes were prepared from the peripheral blood of 40 SLE patients and 11 healthy controls. The expression of LY6E, IFNA1, IFNG, IFNL1, CMPK2 and USP18 mRNAs was determined by qPCR and analyzed via the Mann‒Whitney U test and Pearson correlation coefficient. Each data point represents a log2 (2−△.Ct) value for LY6E in an individual patient (A). The correlations between LY6E mRNA and IFNA1, IFNG, IFNL1, CMPK2 and USP18 mRNAs in CD14 + monocytes prepared from patients with SLE were analyzed (A). Kidney samples from a 21-year-old healthy female and a 36-year-old female patient with lupus nephritis were examined by immunohistochemical staining and analyzed by confocal microscopy, and 3-dimensional (B) and 3-dimensional zoomed-in images (C) are shown. ****P < 0.0001

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X