Fig. 10

Synergistic effects of a combination of IL-1β and IFN-α or IL-1β and ICs in ISGs induction. BMDMs stimulated with IL-1β, IFN-α or ICs alone or in combination for 12 h or 24 h were collected, and the expression of several ISGs as indicated was determined by qPCR. Statistical analysis was performed with two-way ANOVA with Holm‒Sidak multiple comparisons to compare differences among different treatments. *, P < 0.05; **, P < 0.01; ***, P < 0.001 and ****, P < 0.0001