Fig. 11

The proposed model summarizes how LY6E regulates IFN-α- and IC-induced mIL-1β production. Stimulation with either IFN-α or ICs induced LY6E expression. Induction with LY6E activated STAT1 and increased the transcription of CMPK2. The translocation of CMPK2 into mitochondria is, in part, responsible for several events occurring in mitochondria, such as the generation of mtROS and ROS, the increase in oxidized mtDNA and the release of mtDNA into the cytosol. Cytosolic mtDNA then activates the cGAS/STING and TBK1 pathways and the inflammasome pathway. These events lead to an increase in mIL-1β production and secretion. Several LY6E-mediated effects can be reproduced using specific inhibitors, as indicated