Fig. 4

Shear stress stimulation in EOC: mechanosensitive regulation of SREBP2 A + B) Representative images of SREBP2 depicted in red, actin cytoskeleton in white and nuclei in blue. C) Nuclear protein levels of SREBP2 [r.f.u.] in cells exposed to 1 h, 3 h and 24 h of SS and in respective static controls. D) SREBP2 nuclear/cytoplasmic ratio (n/c ratio) in cells exposed to 1 h, 3 h and 24 h of SS and in respective static controls. All experiments were performed in at least 3 independent biological replicates. Statistical significance calculated with t-test and shown as * p < 0.05, ** p < 0.01, *** p < 0.001