Fig. 9

A-D Heatmaps showing graphical representation of metabolome data in SKOV3 cells comparing static controls, static controls treated with cholesterol 10 µg/ml (SKOV3) for 24 h, and cells exposed to SS for 24 h. If not otherwise specified, values represent metabolite concentrations [µM]. (A) cholesterol ester species (CE), (B) Ratios of PCs to choline, (C) phosphatidylcholine species (PC) (D) lyso-phosphatidylcholine species (LPC). Color coding from red-to-blue represents values from high-to-low. Gray entry represents measurement failure. All experiments were performed in at least 3 independent biological replicates. * black indicates statistical significance calculated with t-test between static control and 24 h shear stress, * pink indicates statistical significance calculated with t-test between treatment and control. Significance is shown as * p < 0.05, ** p < 0.01, *** p < 0.001