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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: IKZF1 as a potential therapeutic target for dendritic cell-mediated immunotherapy in IgA nephropathy

Fig. 2

Identification and validation of dendritic cells-related hub genes screened by WGCNA for IgAN. (A) Scatter plots of the GS score and MM for Dendritic cells resting in the darkorange modules. (B) Venn diagram showed intersected genes between WGCNA module (Dendritic cells and darkorange) genes and DEGs (IgAN vs. Control). (C) The KEGG pathway enrichment analysis and (D) the GO (biological process (BP), molecular function (MF), Cellular Component (CC)) enrichment analysis of the intersected genes. (E) The PPI network of the intersected genes. (F) The correlation among intersected genes. (G-L) mRNA expression levels of IKZF1, CCR2, and CCR7 in IgAN mouse model (G-I, n = 5) and anti-Thy1 nephritis rats (J-L, n = 8) models were detected by RT-qPCR. Results are presented as the mean values (± SEM), *P < 0.05, **P < 0.01, ***P < 0.001 versus Control

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Cell Communication and Signaling

ISSN: 1478-811X