Fig. 8
From: IKZF1 as a potential therapeutic target for dendritic cell-mediated immunotherapy in IgA nephropathy
Lenalidomide, as an IKZF1-targeting molecular glue degrader, suppresses immune cell infiltration. (A) mIHC images showed the staining for dendritic cell (CD103, green) and IKZF1 (red) in kidney tissues in anti-Thy-1 nephritis after Len treatment. (B) Quantification of IKZF1+CD103+ DCs in (A). (C-D) Percentage of IKZF1+CD103+ DCs. (E-J) Representative images and quantitative analyses of CD103 (E, H), CD4 (F, I) and CD68 (G, J) expression in kidney tissues after Len treatment. (K-N) mRNA expression levels of CCR2 (K), CCR5 (L), CCR7 (M) and IL7R (N) were detected using qRT-PCR. Data are presented as means ± SEM, n = 5; *P < 0.05, **P < 0.01, ***P < 0.001. Scale bar = 50 μm