Table 1 Analysis of the LD:vinculin-tail (Vin-T) interactions observed in the crystal structure shown in Fig. 6 with PISA [31]. (1) solvation free energy gain. (2) measure of interface specificity with P < 0.5 indicating a specific interaction and P > 0.5 suggesting a non-specific interaction, possibly due to crystal packing
Protomer 1 (Chain ID) | Protomer 2 (Chain ID) | Interface Area (Å2) | ΔiG (kcal/mol)(1) | ΔiG (P-value) (2) |
|---|---|---|---|---|
Vin-T (A) | LD1 (G) | 320.0 | -3.0 | 0.541 |
Vin-T (C) | LD1 (H) | 356.1 | -2.4 | 0.561 |
Vin-T (A) | LD2 (E) | 620.7 | -1.7 | 0.670 |
Vin-T (C) | LD2 (F) | 540.5 | -3.2 | 0.605 |
Vin-T (B) | LD2 (E) | 325.0 | -6.0 | 0.161 |
Vin-T (D) | LD2 (F) | 314.8 | -5.8 | 0.194 |