Fig. 10

BAZ attenuates kainic acid (KA)-induced neurodegeneration in selected mouse hippocampal regions in vivo. A. Representative data for the histopathological analysis of the damaged hippocampal region. The upper two panels are the H/E staining of the hippocampal region (scale bar = 2 mm) and the enlarged CA3 region (scale bar = 200 μm), respectively. The middle two panels are the Fluoro-Jade B staining of the hippocampal region (scale bar = 2 mm) and the enlarged CA3 region (scale bar = 200 μm), respectively. The bottom panel is the TUNEL staining of cells in the CA3 region (scale bar = 60 μm). B. Quantitative data for the number of degenerating neurons in control and kainic acid (KA)-treated mice (n = 3). C. Relative intensity of TUNEL staining in CA3 neuronal cells in control and kainic acid (KA)-treated mice (n = 3). All quantitative data are presented as mean ± S.D. (* or ^# P < 0.05; ** or ^## P < 0.01)