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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Strong protection by bazedoxifene against chemically-induced ferroptotic neuronal death in vitro and in vivo

Fig. 4

Effect of BAZ on the reductase and oxidase activity of PDI in the in-vitro enzymatic assays. A, B. Inhibition by BAZ of the reductase activity of the wild-type PDI-His256 (A) and mutant PDI-Ala256 (B). The reductase activity of PDI was assayed by measuring PDI-mediated insulin aggregation. The assay was repeated three times and similar results were obtained. The data from a representative assay is shown here. C, D. Inhibition by BAZ of the oxidase activity of the wild-type PDI-His256 (C) and mutant PDI-Ala256 (D). The oxidase activity of PDI was assayed by measuring PDI-mediated RNase A refolding. The assay was repeated three times and similar results were obtained. The data from a representative assay is shown here

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Cell Communication and Signaling

ISSN: 1478-811X