Table 1 List of studies indirectly targeting ER-Phagy and associated receptors
From: ER stress and/or ER-phagy in drug resistance? Three coincidences are proof
ER-Phagy/ associated receptors | Inhibitors | Disease condition | Reference studies/ Clinical trials |
|---|---|---|---|
IRE1 inhibitor | MKC8866 | Glioblastoma | [131] |
PERK inhibitor | AMG44 | Cancer | [132] |
PERK inhibitor | GSK2656157 | Pancreatic Cancer | [11] |
ER stress inhibitors (GRP78, PERK, IRE1α, XBP-1, UPR) | Metformin | Endometrial Cancer, Polycystic Ovary Syndrome | [133], NCT02302326 |
ER stress inhibitors | 4-Phenylbutyric acid (4-PBA) | Hepatocellular carcinoma | [134] |
ER stress inhibitors | Tauroursodeoxycholic acid (TUDCA) | Hepatocellular carcinoma | [135] |
FAM134 | SGC-CK2-1 | Osteosarcoma | [136] |
FAM134B | Vitexin | Glioblastoma, Melanoma | [137] |
FAM134B | Z36 | Cervical Cancer | [70] |