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  1. Hypoxia is a critical physiological and pathological condition known to influence various cellular processes, including steroidogenesis. While previous studies, including our own, have highlighted the regulato...

    Authors: Stephen Ariyeloye, Deepika Watts, Mangesh T. Jaykar, Cagdas Ermis, Anja Krüger, Denise Kaden, Barbara K. Stepien, Vasileia Ismini Alexaki, Mirko Peitzsch, Nicole Bechmann, Peter Mirtschink, Ali El-Armouche and Ben Wielockx
    Citation: Cell Communication and Signaling 2025 23:86
  2. Stress granules (SGs) are conserved messenger ribonucleoprotein (mRNP) granules that form through rapid coalescence in the cytoplasm of eukaryotic cells under stressful environments. These dynamic membrane-fre...

    Authors: Jiaxin Li, Linyuan Shen, Kai Wang, Shuang Wu, Yan Wang, Yuheng Pan, Siyu Chen, Ting Zhao, Ye Zhao, Lili Niu, Lei Chen, Shunhua Zhang, Li Zhu and Mailin Gan
    Citation: Cell Communication and Signaling 2025 23:84
  3. Tumor dissemination is a life-threatening event which confers to most cancer-related deaths with limited effective therapeutic option. TNFα-induced protein 2 (TNFAIP2) reveals pro-metastasis potential in sever...

    Authors: Teng Xu, Yaning Wang, Zechen Zhao, Jinsong Wang, Zhenyuan Zhao, Yuemei Yang, Xiaomeng Song and Qingguo Lai
    Citation: Cell Communication and Signaling 2025 23:83
  4. Ferroptosis is a non-apoptotic form of regulated cell death that involves an imbalance in the homeostasis of two elements: iron and lipid hydroperoxides. The accumulation of lipid hydroperoxide serves as a key...

    Authors: Yuting Chen, Yue Dai, Yi Huang, Le Zhang, Cuntai Zhang, Hongyu Gao and Qi Yan
    Citation: Cell Communication and Signaling 2025 23:81
  5. Immunotherapy for liver cancer is used to rejuvenate tumor-infiltrating lymphocytes by modulating the immune microenvironment. Thus, early protective functions of T cell subtypes with tissue-specific residency...

    Authors: Mi-So Park, Hyeonbin Jo, Hyeree Kim, Ji Young Kim, Woong-Yang Park, Yong-Han Paik, Yeup Yoon, Wonseok Kang and Hong-Hee Won
    Citation: Cell Communication and Signaling 2025 23:80
  6. Extracellular vesicles (EVs) are relevant elements for cell-to-cell communication and are considered crucial in host-pathogen interactions by transferring molecules between the pathogen and the host during inf...

    Authors: Jianjun Wang, Xiuping Wang, Hao Luo, Yiping Xie, Hui Cao, Lingxiang Mao, Tingting Liu, Yushan Yue and Hui Qian
    Citation: Cell Communication and Signaling 2025 23:79
  7. Macrophages are the major source of WNT ligands. However, the regulation of WNT expression in macrophages has not been studied. In the present study, we have discovered that activation of canonical β-Catenin s...

    Authors: Rishi Man Chugh, Payel Bhanja, Ryan Zitter, Sumedha Gunewardena, Rajeev Badkul and Subhrajit Saha
    Citation: Cell Communication and Signaling 2025 23:78
  8. Chondrocyte senescence play an essential role in osteoarthritis (OA) progression. Recent studies have shown that snoRNA-derived RNA fragments (sdRNAs) are novel regulators of post-transcriptional gene expressi...

    Authors: Zengfa Deng, Changzhao Li, Shu Hu, Yanlin Zhong, Wei Li, Zhencan Lin, Xiaolin Mo, Ming Li, Dongliang Xu, Dianbo Long, Guping Mao and Yan Kang
    Citation: Cell Communication and Signaling 2025 23:77
  9. Mast cells develop from the myeloid lineage and are released from the bone marrow as immature cells, which then differentiate at the destination tissue based on cues from the local environment. In the liver, m...

    Authors: Steffen K. Meurer, Gina Bronneberg, Christian Penners, Marlies Kauffmann, Till Braunschweig, Christian Liedtke, Michael Huber and Ralf Weiskirchen
    Citation: Cell Communication and Signaling 2025 23:76
  10. Circular dorsal ruffles (CDRs) are large and rounded membrane ruffles that function as precursors of macropinocytosis. We recently reported that CDRs form in Hep3B hepatocellular carcinoma (HCC) cells, but not...

    Authors: Xiaowei Sun, Yanan Li, Yuxin He, Longjiao Cheng, Li Wang, Jinzi Wei, Jianan Chen, Linxuan Du, Zhongyang Shen, Yan Xie, Adam C. Midgley, Wentao Jiang and Sei Yoshida
    Citation: Cell Communication and Signaling 2025 23:75
  11. Current conventional treatment regimens for head and neck squamous cell carcinoma (HNSCC), are poorly effective because of the emergence of resistance mechanisms. Many studies have reported how the tumor micro...

    Authors: Ylenia Ferrara, Debora Latino, Angela Costagliola di Polidoro, Angela Oliver, Annachiara Sarnella, Maria Grazia Caprio, Laura Cerchia, Menotti Ruvo, Annamaria Sandomenico and Antonella Zannetti
    Citation: Cell Communication and Signaling 2025 23:74
  12. Primary cilia facilitate cellular signalling and play critical roles in development, homeostasis, and disease. Their assembly is under the control of Tau-Tubulin Kinase 2 (TTBK2), a key enzyme mutated in patie...

    Authors: David Benk Vysloužil, Ondřej Bernatík, Eva Lánská, Tereza Renzová, Lucia Binó, Andrea Lacigová, Tereza Drahošová, Zdeněk Lánský and Lukáš Čajánek
    Citation: Cell Communication and Signaling 2025 23:73
  13. The epithelial-mesenchymal transition (EMT) is a biological process whereby epithelial cells are transformed into cells with a mesenchymal phenotype. The transcription factor, X-box binding protein 1 splicing ...

    Authors: Kangkang Gao, Mengqi Si, Xinxi Qin, Beibei Zhang, Zongjie Wang, Pengfei Lin, Huatao Chen, Aihua Wang and Yaping Jin
    Citation: Cell Communication and Signaling 2025 23:72
  14. Prostate cancer (PrCa) is a significant health concern, ranking as the second most common cancer in males globally. Genetic factors contribute substantially to PrCa risk, with up to 57% of the risk being attri...

    Authors: Christoffer Löf, Nasrin Sultana, Neha Goel, Samuel Heron, Gudrun Wahlström, Andrew House, Minna Holopainen, Reijo Käkelä and Johanna Schleutker
    Citation: Cell Communication and Signaling 2025 23:71
  15. Neutrophils are the first responders among peripheral immune cells to infiltrate the central nervous system following a traumatic brain injury (TBI), triggering neuroinflammation that can exacerbate secondary ...

    Authors: Lei Li, Ruilong Peng, Cong Wang, Xin Chen, Dilmurat Gheyret, Siyu Guan, Bo Chen, Yafan Liu, Xilei Liu, Yiyao Cao, Cha Han, Jianhua Xiong, Fanjian Li, Taoyuan Lu, Haoran Jia, Kaiji Li…
    Citation: Cell Communication and Signaling 2025 23:70
  16. Fungi are notorious for causing diseases in plants and domestic animals. ABC transporters play pivotal roles in multidrug resistance in fungi, with some ABC proteins indispensable for the pathogenicity of plan...

    Authors: Jing Wang, Chenwen Xiao, Shuang Liang, Muhammad Noman, Yingying Cai, Zhen Zhang, Xueming Zhu, Rongyao Chai, Haiping Qiu, Zhongna Hao, Yanli Wang, Jiaoyu Wang, Guolian Bao, Guochang Sun and Fucheng Lin
    Citation: Cell Communication and Signaling 2025 23:69
  17. Neuronal intranuclear inclusion disease (NIID) is genetically linked to CGG repeat expansion in the 5’-untranslated region of the NOTCH2NLC gene, with nascent polyglycine-containing protein (uN2CpolyG) identified...

    Authors: Yu Shen, Kaiyan Jiang, Dandan Tan, Min Zhu, Yusen Qiu, Pencheng Huang, Wenquan Zou, Jianwen Deng, Zhaoxia Wang, Ying Xiong and Daojun Hong
    Citation: Cell Communication and Signaling 2025 23:68
  18. Synchrotron-radiation nano-X-Ray Fluorescence (XRF) is a cutting-edge technique offering high-resolution insights into the elemental composition of biological tissues, shedding light on metabolic processes and...

    Authors: Bryan Falcones, Maik Kahnt, Ulf Johansson, Barbora Svobodová, Karin A. von Wachenfelt, Charlott Brunmark, Göran Dellgren, Linda Elowsson, Karina Thånell and Gunilla Westergren-Thorsson
    Citation: Cell Communication and Signaling 2025 23:67
  19. Fibrosis remains a major complication in several chronic diseases, including systemic sclerosis (SSc). Plasmacytoid dendritic cells (pDCs) are innate immune cells that play a key role in the development of fib...

    Authors: Beatriz H. Ferreira, Inês S. Silva, Andreia Mendes, Fátima Leite-Pinheiro, Adrienne W. Paton, James C. Paton, Iola F. Duarte, Philippe Pierre and Catarina R. Almeida
    Citation: Cell Communication and Signaling 2025 23:66
  20. Acute pneumonia is a kind of widespread inflammatory pathological process. Dihydrocaffeic acid (DA), metabolite of chlorogenic acid, possesses potent pharmacologic activity for the therapy of a wide range of d...

    Authors: Guanjun Li, Huiying Li, Peili Wang, Xinzhou Zhang, Wenhua Kuang, Ling Huang, Ying Zhang, Wei Xiao, Qingfeng Du, Huan Tang and Jigang Wang
    Citation: Cell Communication and Signaling 2025 23:65
  21. Vimentin is a type III intermediate filament protein that plays an important role in cytoskeletal mechanics. It is now known that vimentin also has distinct functions outside the cell. Recent studies show the ...

    Authors: Łukasz Suprewicz, Krzysztof Fiedoruk, Karol Skłodowski, Evan Hutt, Magdalena Zakrzewska, Alicja Walewska, Piotr Deptuła, Agata Lesiak, Sławomir Okła, Peter A. Galie, Alison E. Patteson, Paul A. Janmey and Robert Bucki
    Citation: Cell Communication and Signaling 2025 23:64
  22. Immune response gene 1 (IRG1) is highly expressed in mitochondria of macrophages in a pro-inflammatory state. IRG1 and its metabolites play important roles in infection, immune-related diseases and tumor progress...

    Authors: Liwu Zeng, Yaxin Wang, Yongzhou Huang, Wenchang Yang, Pei Zhou, Yaqi Wan, Kaixiong Tao and Ruidong Li
    Citation: Cell Communication and Signaling 2025 23:63
  23. Epilepsy is a neurological disorder characterized by recurrent seizures, tightly associated with neuroinflammation. Activation of inflammatory cells and molecules in damaged nervous tissues plays a pivotal rol...

    Authors: Guanjun Li, Ling Huang, Di Gu, Peili Wang, Letai Yi, Wenhua Kuang, Ying Zhang, Junzhe Zhang, Dandan Liu, Qiaoli Shi, Huan Tang, Jichao Sun, Guohua Zeng, Xin Peng and Jigang Wang
    Citation: Cell Communication and Signaling 2025 23:62
  24. Animal models are crucial for elucidating the pathological mechanisms underlying Parkinson’s disease (PD). Unfortunately, most of transgenic mouse models fail to manifest pathological changes observed in PD pa...

    Authors: Nan Dong, Zhenli Xie, Anqi Wei, Yuxin Yang, Yongning Deng, Xu Cheng, Bianbian Wang, Yang Chen, Yuhao Gu, Jingyu Yao, Yuhao Qin, Chaowen Zheng, Xi Zhang, Yuqing Zhang, Xinjiang Kang, Guoqing Chen…
    Citation: Cell Communication and Signaling 2025 23:61
  25. Extracellular Vesicles (EVs) play a crucial role in cell differentiation. Despite its role as a well-established vertebrate model, little is known about EVs during zebrafish embryogenesis. This study investiga...

    Authors: Linda-Marie Mulzer, Tim Felger, Luis E. Muñoz, Gesa Engl, Heiko Reutter, Mario Schiffer, Leila Pourtalebi Jahromi, Fanni Annamária Boros, Friederike Zunke, Philipp Arnold and Alina C. Hilger
    Citation: Cell Communication and Signaling 2025 23:60
  26. Sex determination mechanisms vary significantly across different chromosomal systems and evolutionary contexts. Nonetheless, the regulatory framework governing the multi-sex chromosome system (X1X1X2X2/X1X2Y) rem...

    Authors: Haixia Zhao, Jun Li, Zhizhong Xiao and Yongshuang Xiao
    Citation: Cell Communication and Signaling 2025 23:59
  27. Ionizing radiation (IR) poses a significant threat to male fertility by inducing substantial changes in the testis, yet the mechanisms underlying IR-induced spermatogenesis disorders remain poorly understood, ...

    Authors: Hongjian Zhou, Zhipeng Xu, Chun Jiang, Qiuyue Wu, Chuanyue Zhang, Zhenyu Liu, Xiaoxue Zhang, Weiwei Li, Yujia Pang, Jing Zhang, Wenju Pan, Min Chen and Xinyi Xia
    Citation: Cell Communication and Signaling 2025 23:58
  28. Coagulation factors are responsible for blood clot formation yet have also non-canonical functions as signalling molecules. In this context, they can activate protease-activated receptors (PARs) ubiquitously e...

    Authors: Anxhela Habibi, Wolfram Ruf and Leon Schurgers
    Citation: Cell Communication and Signaling 2025 23:57
  29. Intracellular membraneless organelles formed by liquid-liquid phase separation (LLPS) function in diverse physiological processes and have been linked to tumor-promoting properties. The nucleolus is one of the...

    Authors: Shaoxuan Cheng, Zhiyuan Qiu, Ziyi Zhang, Yuxuan Li, Yue Zhu, Yuxin Zhou, Yinghui Yang, Yaowen Zhang, Dian Yang, Yingqiu Zhang, Han Liu, Zhaoxia Dai, Shu-Lan Sun and Shuyan Liu
    Citation: Cell Communication and Signaling 2025 23:56
  30. Wound healing is a highly coordinated process driven by intricate molecular signaling and dynamic interactions between diverse cell types. Nod-like receptor pyrin domain-containing protein 3 (NLRP3) has been i...

    Authors: Jiamin Zhao, Shuangyi Zhang, Zhiguo Gong, Wei Mao, Wenhui Bao, Qianru Li, Yunjie Bai, Feifei Gao and Shuang Feng
    Citation: Cell Communication and Signaling 2025 23:55
  31. Neuropilin-1 (NRP1) is a transmembrane protein involved in surface receptor complexes for a variety of extracellular signals. NRP1 expression in human cancers is associated with prominent angiogenesis and adva...

    Authors: Claudia Palazzo, Roberta Mastrantonio, Noemi Gioelli, Erika Testa, Francesco Recco, Donatella Lucchetti, Giulia Villari, Alessio D’Alessio, Alessandro Sgambato, Flavio Mignone, Guido Serini, Maria Teresa Viscomi and Luca Tamagnone
    Citation: Cell Communication and Signaling 2025 23:54
  32. FLT3 mutations occur in approximately 25% of all acute myeloid leukemia (AML) patients. While several FLT3 inhibitors have received FDA approval, their use is currently limited to combination therapies with ch...

    Authors: Helene Sieberer, Michela Luciano, Diana Amend, Constantin Blöchl, Anna Eglseer, Alina Steinkellner, Sebastian Rieser, Ancuela Andosch, Philip Steiner, Laura Hummer, Peter W. Krenn, Hieu-Hoa Dang, Christian G. Huber, Fritz Aberger, Theresa Neuper and Jutta Horejs-Hoeck
    Citation: Cell Communication and Signaling 2025 23:53
  33. Oxidative stress-associated proximal tubular cells (PTCs) damage is an important pathogenesis of hypertensive renal injury. We previously reported the protective effect of VEGFR3 in salt-sensitive hypertension...

    Authors: Qiuwen Wu, Jiaxin Fu, Bin Zhu, Wei Meng, Jingyi Ma, Ying Lv, Wenqi Zhao, Fan Wang, Jingjin Liu, Yongshun Wang, Cong Peng and Shuo Zhang
    Citation: Cell Communication and Signaling 2025 23:52
  34. Cancer-associated fibroblasts (CAFs) are key components of the pancreatic adenocarcinoma (PAAD) tumor microenvironment (TME), where they promote tumor progression and metastasis through immunosuppressive funct...

    Authors: Liuyuan Xia, Xin Guo, Dong Lu, Yixin Jiang, Xiaohui Liang, Yiwen Shen, Jiayi Lin, Lijun Zhang, Hongzhuan Chen, Jinmei Jin, Xin Luan and Weidong Zhang
    Citation: Cell Communication and Signaling 2025 23:51
  35. Degeneration of cochlear spiral ganglion neurons (SGNs) leads to irreversible sensorineural hearing loss (SNHL), as SGNs lack regenerative capacity. Although cochlear glial cells (GCs) have some neuronal diffe...

    Authors: Man Wang, Yuechen Han, Weibin An, Xue Wang, Fang Chen, Junze Lu, Yu Meng, Yan Li, Yanqing Wang, Jingxin Li, Chunjie Zhao, Renjie Chai, Haibo Wang, Wenwen Liu and Lei Xu
    Citation: Cell Communication and Signaling 2025 23:50
  36. Efferocytosis is a mechanism by which phagocytes efficiently clear apoptotic cells, averting their secondary necrosis and the subsequent release of potentially immunogenic or cytotoxic substances that can trig...

    Authors: Hui Tao, Ruilin Ma, Jianjian Cui, Zejun Yang, Wencong He, Yanan Li and Yin Zhao
    Citation: Cell Communication and Signaling 2025 23:49
  37. Ovarian cancer (OC), particularly high-grade serous ovarian carcinoma (HGSOC), is the leading cause of mortality from gynecological malignancies worldwide. Despite the initial effectiveness of treatment, acqui...

    Authors: Yinan Xiao, Yu Wu, Qilong Wang, Mo Li, Chaolin Deng and Xiaoyang Gu
    Citation: Cell Communication and Signaling 2025 23:48
  38. One hallmark of cancer is the upregulation and dependency on glucose metabolism to fuel macromolecule biosynthesis and rapid proliferation. Despite significant pre-clinical effort to exploit this pathway, addi...

    Authors: Monika Komza, Jesminara Khatun, Jesse D. Gelles, Andrew P. Trotta, Ioana Abraham-Enachescu, Juan Henao, Ahmed Elsaadi, Andriana G. Kotini, Cara Clementelli, JoAnn Arandela, Sebastian El Ghaity-Beckley, Agneesh Barua, Yiyang Chen, Mirela Berisa, Bridget K. Marcellino, Eirini P. Papapetrou…
    Citation: Cell Communication and Signaling 2025 23:47
  39. The hepatocyte growth factor (HGF) along with its receptor (c-MET) are crucial in preserving standard cellular physiological activities, and imbalances in the c-MET signaling pathway can lead to the developmen...

    Authors: Yang Xia, Chunye Huang, Min Zhong, Hongguang Zhong, Ruiwen Ruan, Jianping Xiong, Yangyang Yao, Jing Zhou and Jun Deng
    Citation: Cell Communication and Signaling 2025 23:46
  40. Glutamine is the most abundant amino acid in human serum, and it can provide carbon and nitrogen for biosynthesis, which is crucial for proliferating cells. Moreover, it is widely known that glutamine metaboli...

    Authors: Ding Nan, Weiping Yao, Luanluan Huang, Ruiqi Liu, Xiaoyan Chen, Wenjie Xia, Hailong Sheng, Haibo Zhang, Xiaodong Liang and Yanwei Lu
    Citation: Cell Communication and Signaling 2025 23:45
  41. Initially, it was believed that glycolysis and DNA damage repair (DDR) were two distinct biological processes that independently regulate tumor progression. The former metabolic reprogramming rapidly generates...

    Authors: Fengyao Sun, Wen Li, Ruihang Du, Mingchan Liu, Yi Cheng, Jianxing Ma and Siyuan Yan
    Citation: Cell Communication and Signaling 2025 23:44
  42. Fat mass and obesity-associated protein (FTO) was the first m6A demethylase identified, which is responsible for eliminating m6A modifications in target RNAs. While it is well-established that numerous cytosol...

    Authors: Junjie Gou, Jingjing Bi, Kexin Wang, Lei Lei, Yanli Feng, Zengqi Tan, Jiaojiao Gao, Yanan Song, Enci Kang, Feng Guan and Xiang Li
    Citation: Cell Communication and Signaling 2025 23:43
  43. NOD-like receptor family CARD domain-containing 5 (NLRC5) is a major transcriptional coactivator of MHC class I genes. NLRC5 is the largest member of the NLR family and contains three domains: an untypical cas...

    Authors: Haiqing Zhu, Chengwei Xiao, Jiahua Chen, Bao Guo, Wenyan Wang, Zhenhai Tang, Yunxia Cao, Lei Zhan and Jun-hui Zhang
    Citation: Cell Communication and Signaling 2025 23:42
  44. Asthenozoospermia (ASZ) accounts for about 20-40% of male infertility, and genetic factors, contributing to 30-40% of the causes of ASZ, still need further exploration. Radial spokes (RSs), a T-shaped macromol...

    Authors: Tingwenyi Hu, Xiangrong Tang, Tiechao Ruan, Shunhua Long, Guicen Liu, Jing Ma, Xueqi Li, Ruoxuan Zhang, Guoning Huang, Ying Shen and Tingting Lin
    Citation: Cell Communication and Signaling 2025 23:41
  45. Autophagic activation in immune cells, gut microbiota dysbiosis, and metabolic abnormalities have been reported separately as characteristics of systemic lupus erythematosus (SLE). Elucidating the crosstalk am...

    Authors: Jiaxuan Chen, Quanren Pan, Lu Lu, Xiaorong Huang, Shuting Wang, Xiaoxian Liu, Jiaqi Lun, Xiaowei Xu, Hongyong Su, Fengbiao Guo, Lawei Yang, Liuyong You, Haiyan Xiao, Wenying Luo, Hua-feng Liu and Qingjun Pan
    Citation: Cell Communication and Signaling 2025 23:40
  46. Cancer-associated fibroblasts (CAFs) are a pivotal component of the tumor microenvironment (TME), playing key roles in tumor initiation, metastasis, and chemoresistance. While glycosylation is known to regulat...

    Authors: Jing Li, Xueting Ren, Lin Cao, Kaixiang Min, Meng Wang, Shuai Lin, Lei Lei, Zengqi Tan, Xiaoliang Cheng, Xiang Li and Feng Guan
    Citation: Cell Communication and Signaling 2025 23:39
  47. TGF-β1 is the most abundant cytokine in bone, in which it serves as a vital factor to interdict adipogenesis and osteogenesis of bone marrow-derived mesenchymal stem cells (BM-MSCs). However, how TGF-β1 concur...

    Authors: Ying-Wen Wang and Ching-Wei Luo
    Citation: Cell Communication and Signaling 2025 23:38
  48. FGF21 regulates local and systemic metabolic homeostasis. High serum FGF21 was found in obesity, metabolic syndrome, type 2 diabetes mellitus, and coronary heart disease. The pathways linking obesity and breas...

    Authors: Stella Maris Ranuncolo, Eduardo Armanasco, Myriam Nuñez, Laura Yuan, Sujhrob Makhkamov and Mariana S. De Lorenzo
    Citation: Cell Communication and Signaling 2025 23:37
  49. Authors: Jiaxin Ou, Kangxin Li, Hui Yuan, Shaohua Du, Tingting Wang, Qiannan Deng, Huimei Wu, Weiyan Zeng, Kui Cheng and Kutty Selva Nandakumar
    Citation: Cell Communication and Signaling 2025 23:33

    The original article was published in Cell Communication and Signaling 2025 23:14

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 8.2
    5-year Journal Impact Factor: 8.0
    Source Normalized Impact per Paper (SNIP): 1.569
    SCImago Journal Rank (SJR): 2.308

    Speed 2024
    Submission to first editorial decision (median days): 6
    Submission to acceptance (median days): 93

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    Downloads: 2,816,255
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