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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Epigenetic modulation of the NLRP6 inflammasome sensor as a therapeutic modality to reduce necroptosis-driven gastrointestinal mucosal dysfunction in HIV/SIV infection

Fig. 2

Genes with methylation changes throughout CGIs associated with inflammatory response, cellular adhesion, and proliferation. Biological processes identified using Gene Ontology enrichment analysis of hypomethylated genes in VEH/SIV (red) and THC/SIV (blue) compared to controls or in VEH/SIV relative to THC/SIV RMs (dark green) (A-C) or hypermethylated genes in THC/SIV compared to control RMs (light green) (B&D). Number of differentially methylated CpGs in the CGIs of NLRP6 (E), LEP (F), PCDH17 (G), CDH7 (H), SFRP1 (I), TERT (J), and the Δβ-values in promoter associated CGIs of SFRP1, NLRP6, LEP, and CDH7 (K). DMSs with p-value ≤ 0.05, absolute Δβ-value > 0.1. Controls refer to uninfected controls

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Cell Communication and Signaling

ISSN: 1478-811X