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  1. Mesenchymal stromal cells belong to a diverse collection of cells in different states that are poorly characterized in soft-tissue sarcomas. In this study, we explored tumor growth-regulatory signaling between...

    Authors: Yue Zhang, Karim Katkhada, Liu Zhen Meng, Binbin Zhao, Shanlin Tong, Wiem Chaabane, Aditi Kallai, Nicholas P. Tobin, Arne Östman, Alessandro Mega and Monika Ehnman
    Citation: Cell Communication and Signaling 2025 23:184
    Content type: Research Published on:

  2. Enterovirus 71 (EV71) is a major etiologic pathogen for hand-foot-and-mouth disease (HFMD) in young children. Severe cases of EV71 infection could lead to neurological complications and even death, while the m...

    Authors: Xiaoyan Tian, Bingxin Liu, Linrun Li, Meng Yuan, Qiao You, Rui Zhang, Deyan Chen, Min Cheng, Nan Zheng, Miao He and Zhiwei Wu
    Citation: Cell Communication and Signaling 2025 23:183
    Content type: Research Published on:

  3. Trained immunity serves as a de facto memory for innate immune responses, resulting in long-term functional reprogramming of innate immune cells. It enhances resistance to pathogens and augments immunosurveillanc...

    Authors: Weinian Liao, Xiaodong Zai, Jun Zhang and Junjie Xu
    Citation: Cell Communication and Signaling 2025 23:182
    Content type: Review Published on:

  4. The development of morphine tolerance presents a major clinical challenge in the effective management of severe pain. This study aims to explore the mechanisms underlying morphine tolerance from a novel perspe...

    Authors: Qingyan Tian, Haiyue Guo, Mengyao Zhang, Kunmao Jiang, Fan Hu, Yan Xu, Li Wan, Xiaokai Zhou, Yinbing Pan, Wentao Liu and Chun-Yi Jiang
    Citation: Cell Communication and Signaling 2025 23:181
    Content type: Research Published on:

  5. Local interstitial acidosis in chronic kidney disease (CKD) induces inflammatory responses and dedifferentiation of proximal tubule cells (PTCs), disrupting cellular crosstalk through cytokine and COX-2 metabo...

    Authors: Marie-Christin Schulz, Nathalie Wolff, Michael Kopf and Micheal Gekle
    Citation: Cell Communication and Signaling 2025 23:180
    Content type: Research Published on:

  6. About 40% of relapsed or non-responder tumors exhibit therapeutic resistance in the absence of a clear genetic cause, suggesting a pivotal role of intracellular communication. A deeper understanding of signali...

    Authors: Valeria Bica, Veronica Venafra, Giorgia Massacci, Simone Graziosi, Sara Gualdi, Gessica Minnella, Federica Sorà, Patrizia Chiusolo, Maria Elsa Brunetti, Gennaro Napolitano, Massimo Breccia, Dimitrios Mougiakakos, Martin Böttcher, Thomas Fischer, Livia Perfetto and Francesca Sacco
    Citation: Cell Communication and Signaling 2025 23:179
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2025 23:205

  7. Extracellular vesicles (EVs) originating from testicular somatic cells act as pivotal intermediaries in cell signaling crosstalk between spermatogenic cells and the testicular microenvironment. The intricate b...

    Authors: Heran Cao, Huihui Gao, Yan Li, Long Li, Shujuan Liu, Tianqi Jin, Yang Wang, Ye Gong, Shuiqiao Yuan and Wuzi Dong
    Citation: Cell Communication and Signaling 2025 23:178
    Content type: Research Published on:

  8. Hypoxia is a common feature of solid malignancies, including cutaneous melanoma (CM). Hypoxia-inducible factor (HIF)-1α and HIF-2α orchestrate cellular responses to hypoxia and coordinate a transcriptional pro...

    Authors: Arianna Bellazzo, Barbara Montico, Roberto Guerrieri, Francesca Colizzi, Agostino Steffan, Jerry Polesel and Elisabetta Fratta
    Citation: Cell Communication and Signaling 2025 23:177
    Content type: Review Published on:

  9. Renal fibrosis represents the final common pathological manifestation of chronic kidney disease (CKD), yet the underlying mechanism remains elusive, and there is still a lack of effective targeted therapeutic ...

    Authors: Yingxian Yang, Shuiqin Gong, Chun Zhou, Wang Xin, Shaozong Qin, Mengying Yao, Qigang Lan, Wenhao Liao, Jinghong Zhao and Yinghui Huang
    Citation: Cell Communication and Signaling 2025 23:176
    Content type: Research Published on:

  10. Monocyte chemoattractant protein-induced protein 3 (MCPIP3), also called Regnase-3 and encoded by the ZC3H12C gene, is a member of the MCPIP family of RNases. Previous studies showed that MCPIP1 in keratinocytes ...

    Authors: Agata Lichawska-Cieslar, Weronika Szukala, Pawel Pilat, Leopold Eckhart, Jacek C Szepietowski and Jolanta Jura
    Citation: Cell Communication and Signaling 2025 23:175
    Content type: Research Published on:

  11. STX12 (syntaxin12 or syntaxin13), a member of the SNARE protein family, plays a crucial role in intracellular vesicle transport and membrane fusion. Our previous research demonstrated that Stx12 knockout mice exh...

    Authors: Dan-Hua Liu, Fang Li, Run-Zhou Yang, Zhuanbin Wu, Xiao-Yan Meng, Sen-Miao Li, Wen-Xiu Li, Jia-Kang Li, Dian-Dian Wang, Rui-Yu Wang, Shu-Ang Li, Pei-Pei Liu and Jian-Sheng Kang
    Citation: Cell Communication and Signaling 2025 23:174
    Content type: Research Published on:

  12. Electrotaxis, the directed cell movement in direct current electric field (dcEF), is crucial for wound healing and development. We recently proposed a biphasic electrotaxis mechanism, where an initial rapid re...

    Authors: Jagoda Gorzkowska, Wiktoria Kozak, Sylwia Bobis-Wozowicz, Ivan Cherepashuk, Zbigniew Madeja and Sławomir Lasota
    Citation: Cell Communication and Signaling 2025 23:173
    Content type: Research Published on:

  13. Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the destruction of insulin-producing β-cells in the pancreas. Emerging evidence suggests that infections, including Toxoplasma gondii (T. ...

    Authors: Kimia Moradi, Reyhaneh Moghaddami, Arshad Ghaffari-Nasab, Monir Khordadmehr, Abdol Sattar Pagheh, Hossein Mosajakhah, Sahar Rezaei, Esmaeil Gharepapagh, Mahdi Ahmadi, Mahbobeh Montazeri, Hossein Pazoki and Ehsan Ahmadpour
    Citation: Cell Communication and Signaling 2025 23:172
    Content type: Research Published on:

  14. The cGAS-STING signaling pathway serves as a critical link between DNA sensing and innate immunity, and has tremendous potential to improve anti-tumor immunity by generating type I interferons. However, STING ...

    Authors: Siwei Wang, Lu Qin, Furong Liu and Zhanguo Zhang
    Citation: Cell Communication and Signaling 2025 23:171
    Content type: Review Published on:

  16. Lysyl oxidases (LOX/LOXL1-4) are crucial for cancer progression, yet their transcriptional regulation, potential therapeutic targeting, prognostic value and involvement in immune regulation remain poorly under...

    Authors: Qingyu Xu, Ling Ma, Alexander Streuer, Eva Altrock, Nanni Schmitt, Felicitas Rapp, Alessa Klär, Verena Nowak, Julia Obländer, Nadine Weimer, Iris Palme, Melda Göl, Hong-hu Zhu, Wolf-Karsten Hofmann, Daniel Nowak and Vladimir Riabov
    Citation: Cell Communication and Signaling 2025 23:169
    Content type: Research Published on:

  17. We previously discovered that HOXC6 was the most significantly upregulated gene in right-sided colon cancer compared to left-sided colon cancer according to our previous study; however, the role of HOXC6 in micro...

    Authors: Lina Qi, Biting Zhou, Jiani Chen, Kailun Xu, Kailai Wang, Shu Zheng, Wangxiong Hu and Yanmei Yang
    Citation: Cell Communication and Signaling 2025 23:168
    Content type: Research Published on:

  18. Aging is associated with a reduction in skeletal muscle fiber size and number, leading to a decline in physical function and structural integrity—a condition known as sarcopenia. This syndrome is further chara...

    Authors: Giulia Gentile, Ferdinando De Stefano, Carmela Sorrentino, Rosa D’Angiolo, Carmine Lauretta, Pia Giovannelli, Antimo Migliaccio, Gabriella Castoria and Marzia Di Donato
    Citation: Cell Communication and Signaling 2025 23:167
    Content type: Review Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2025 23:225

  19. Prenatal stress exposure irreversibly impairs mitochondrial dynamics, including mitochondrial trafficking and morphology in offspring, leading to neurodevelopmental and neuropsychiatric disorders in adulthood....

    Authors: Gee Euhn Choi, Ji Yong Park, Mo Ran Park, Chang Woo Chae, Young Hyun Jung, Jae Ryong Lim, Jee Hyeon Yoon, Ji Hyeon Cho and Ho Jae Han
    Citation: Cell Communication and Signaling 2025 23:166
    Content type: Research Published on:

  20. The nuclear factor kappa B (NF-κB) signalling pathway plays a crucial role in the regulation of inflammation, and previous research from our lab and others suggests that c-Ski has potential anti-inflammatory e...

    Authors: Yan Peng, Ren-Ping Xiong, Bo Wang, Xing Chen, Ya-Lie Ning, Yan Zhao, Nan Yang, Jing Zhang, Chang-Hong Li, Yuan-Guo Zhou and Ping Li
    Citation: Cell Communication and Signaling 2025 23:165
    Content type: Research Published on:

  21. Hypoxia, a key feature of most solid tumours, including head and neck cancer, reduces radiotherapy efficacy by promoting radiation resistance through micro-environmental and genomic alterations. Addressing the...

    Authors: Jie Feng, Varun Pathak, Niall M. Byrne, Sarah Chambers, Tongchuan Wang, Rayhanul Islam, Reinhold J. Medina and Jonathan A. Coulter
    Citation: Cell Communication and Signaling 2025 23:164
    Content type: Research Published on:

  22. TNBC is an aggressive metastatic cancer that poses considerable treatment challenges because of its acquired drug resistance towards the existing targeted and hormonal therapies. The epigenetic modulation incl...

    Authors: Snehal Nimal, Navanath Kumbhar, Manasi S. Pote, Rahul Bankar, Mahemud Shaikh and Rajesh Gacche
    Citation: Cell Communication and Signaling 2025 23:163
    Content type: Research Published on:

  23. Mutation in the internal tandem duplication sequence of the FLT3 gene (FLT3-ITD) is linked to a poor clinical prognosis in acute myeloid leukemia (AML) patients. FLT3 inhibitors have demonstrated efficacy in i...

    Authors: Tianxin Zhang, Yuchen Li, Wenhao Liao, Yu Mou, Xue Zhan, Qiongying Hu, Ziyi Zhao and Daqian Xiong
    Citation: Cell Communication and Signaling 2025 23:162
    Content type: Research Published on:

  24. Extracellular vesicles (EVs) and the extracellular matrix (ECM) are essential in maintaining bone and joint health by facilitating intercellular communication, regulating tissue processes and providing structu...

    Authors: Peng Wang, Johanna F. A. Husch, Onno J. Arntz, Peter M. van der Kraan, Fons A. J. van de Loo and Jeroen J. J. P. van den Beucken
    Citation: Cell Communication and Signaling 2025 23:161
    Content type: Review Published on:

  25. Exposure to traumatic noise triggers cochlear damage and consequently causes permanent sensorineural hearing loss. However, effective treatment strategies for noise-induced hearing loss (NIHL) are lacking. Sir...

    Authors: Yuelian Luo, Haoyang Wu, Xin Min, Yi Chen, Wenting Deng, Minjun Chen, Chuxuan Yang and Hao Xiong
    Citation: Cell Communication and Signaling 2025 23:160
    Content type: Research Published on:

  26. Tuberculosis (TB) is a contagious disease and the second leading cause of death worldwide. The Bacille Calmette–Guérin (BCG) vaccine, the only licensed TB vaccine, has insufficient protective efficacy in adult...

    Authors: Jin-Seung Yun, Soo-Min Kim, Jin Sil Lee, Su Hyun Jeong, Hyeryeon Oh, Panmo Son, Sunghyun Kim, Young-Ran Lee, Eunkyung Shin, Sang-Jun Ha, Yong-Woo Jung, Dokeun Kim, Hye-Sook Jeong and Won Il Choi
    Citation: Cell Communication and Signaling 2025 23:159
    Content type: Research Published on:

  27. Remodeling of the mitochondrial network is implicated in myogenesis. Remodeling processes including mitochondrial fission, mitophagy, and biogenesis are important as they finetune the mitochondrial network to ...

    Authors: Fasih A. Rahman, Jasmine M. Friedrich Yap, Tyler M. Joseph, Amanda M. Adam, Sarah M. Chapman and Joe Quadrilatero
    Citation: Cell Communication and Signaling 2025 23:158
    Content type: Research Published on:

  28. NAMPT is an important intracellular metabolic enzyme (iNAMPT) regulating the NAD+ salvage pathway. However, increased cellular stress (infection, inflammation, hypoxia) promotes the secretion of extracellular NAM...

    Authors: Marisela Rodriguez, Haifei Xu, Annie Hernandez, Julia Ingraham, Jason Canizales, Fernando Teran Arce, Sara M. Camp, Skyler Briggs, Aikseng Ooi, James M. Burke, Jin H. Song and Joe G.N. Garcia
    Citation: Cell Communication and Signaling 2025 23:157
    Content type: Research Published on:

  29. Recent studies have shown that the antitumor immunity of adaptive immune cells is regulated by Vitamin A (retinoic acid, RA). However, it remains unclear whether RA and retinoic acid receptor (RAR) signaling c...

    Authors: Guichao Liu, Qiang Quan, Lanhong Pan, Haibo Duan, Guojun Zhang, Ke Li, Xinhai Zhu, Dongdong Zhang, Peng Li and Jianfu Zhao
    Citation: Cell Communication and Signaling 2025 23:156
    Content type: Research Published on:

  31. Transcription factor 4 (TCF4) is a member of the basic helix-loop-helix (bHLH) family of transcription factors that guides proper embryogenesis, particularly neurogenesis, myogenesis, heart development and hem...

    Authors: Nikola Sozańska, Barbara P. Klepka, Anna Niedzwiecka, Lilia Zhukova, Michał Dadlez, Beata Greb-Markiewicz, Andrzej Ożyhar and Aneta Tarczewska
    Citation: Cell Communication and Signaling 2025 23:154
    Content type: Research Published on:

  32. Oncogenes drive cancer progression, but few are active exclusively in tumor cells. Connexins (Cxs), traditionally recognized as ion channel proteins, can localize to the nucleus and regulate gene expression, p...

    Authors: Ainoa Fernández-Olivares, Viviana P Orellana, Jesús Llanquinao, Gonzalo Nuñez, Pablo Pérez-Moreno, Sebastián Contreras-Riquelme, Alberto JM Martin, Fabio Mammano, Ivan E Alfaro, Juan F Calderón, Jimmy Stehberg, Mauricio A Sáez and Mauricio A. Retamal
    Citation: Cell Communication and Signaling 2025 23:153
    Content type: Research Published on:

  33. Resistance to the proteasome inhibitor bortezomib (BTZ) poses a formidable therapeutic challenge in multiple myeloma (MM). Our study aims to analyze the mechanism by which exosomes heat shock 70 kDa protein 9 ...

    Authors: Min Shi, Na Shen, Xiangyu Liu, Jiapei Yu, Xuxing Shen, Ying Chen, Yuan Xia and Lijuan Chen
    Citation: Cell Communication and Signaling 2025 23:152
    Content type: Research Published on:

  34. Autophagy is a lysosome-dependent degradation pathway for recycling intracellular materials and removing damaged organelles, and it is usually considered a prosurvival process in response to stress stimuli. Ho...

    Authors: Xiangliang Huang, Hao Yan, Zhifei Xu, Bo Yang, Peihua Luo and Qiaojun He
    Citation: Cell Communication and Signaling 2025 23:151
    Content type: Review Published on:

  35. Reduced oocyte quality is a key factor in age-related fertility decline, and there are no effective treatments available. The secretome of mesenchymal stem cells (MSC-sec) contains various bioactive factors an...

    Authors: Jing Zhou, Cheng Li, Xin Mi, Jiali Zhou, Caiyi Chen, Jiayi Ren, Ran Liu, Gang Liu, Zi-Jiang Chen, Yingying Qin, Keliang Wu and Shidou Zhao
    Citation: Cell Communication and Signaling 2025 23:150
    Content type: Research Published on:

  36. Dermatomyositis (DM) is an idiopathic inflammatory myopathy. Anti-MDA5 antibody positive DM (MDA5 + DM) is a distinct subtype of the disease. The model of anti-MDA5 antibody positive DM has been already report...

    Authors: Li-Qin Zhao, Xue-Qing Yang, Qian Niu, Xiao Feng, He-De Zhang, Shu-Yi Ye, Li-Juan Jiang, Fan Yu, Hong Ye and Wan-Li Ma
    Citation: Cell Communication and Signaling 2025 23:149
    Content type: Research Published on:

  37. Acute kidney injury (AKI) is defined by a significant reduction in renal function, which subsequently impairs coagulation and activates the inflammatory immune response, ultimately resulting in damage to renal...

    Authors: Ya-Wei Guo, Qi Luo, Meng Lu, Xiang-Bin Zeng, Yu-Min Zhang, Yue-Ling Lin, Xu-Ran Guo, Rong Ma and Zhang-Yin Ming
    Citation: Cell Communication and Signaling 2025 23:148
    Content type: Research Published on:

  38. In the course of tumor treatment, radiation therapy (RT) not only kills cancer cells, but also induces complex biological effects in non-malignant cells around cancer cells. These biological effects such as an...

    Authors: Linhui Zheng, Wenqi Cai, Yuan Ke, Xiaoyan Hu, Chunqian Yang, Runze Zhang, Huachao Wu, Dong Liu, Haijun Yu and Chaoyan Wu
    Citation: Cell Communication and Signaling 2025 23:147
    Content type: Review Published on:

  39. Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the deposition of immune complexes (ICs) in various organs, especially the kidney, leading to lupus nephritis, one of the major and...

    Authors: Jenn-Haung Lai, De-Wei Wu, Chuan-Yueh Huang, Li-Feng Hung, Chien-Hsiang Wu, Shuk-Man Ka, Ann Chen, Jing-Long Huang and Ling-Jun Ho
    Citation: Cell Communication and Signaling 2025 23:146
    Content type: Research Published on:

  40. Immunotherapy has significantly improved outcomes for cancer patients; however, its clinical benefits vary among patients and its efficacy across breast cancer subtypes remains unclear. To enhance immunotherap...

    Authors: Adviti Naik, Remy Thomas, Aljazi Al-Khalifa, Hanan Qasem and Julie Decock
    Citation: Cell Communication and Signaling 2025 23:145
    Content type: Research Published on:

  41. Sleep disorders occur frequently among patients with Parkinson’s disease (PD). Neurotransmitters and neurosteroids are known to be involved in various neurophysiological processes, including sleep development....

    Authors: Cui-Hong Ma, Ning Ren, Jing Xu and Lei Chen
    Citation: Cell Communication and Signaling 2025 23:144
    Content type: Research Published on:

  43. The LPS-TLR4 immune response is a critical mechanism in the body's defense against Gram-negative bacterial infections, yet its dysregulation can lead to severe inflammatory diseases. Lipopolysaccharide (LPS), ...

    Authors: Ruiqin Luo, Yuexin Yao, Zhuo Chen and Xiaoming Sun
    Citation: Cell Communication and Signaling 2025 23:142
    Content type: Review Published on:

  44. Keloid is a typical skin fibrotic disease with unclear mechanisms and limited therapeutic options. Fibroblast-induced fibrogenesis is a crucial cause of KD. However, the types of cells involved in fibroblast f...

    Authors: Xiangguang Shi, Xueyi Xia, Yang Xiao, Ying Zhang, Yiyi Gong, Yahui Chen, Chenyi Shi, Wei Wang, Jianlan Liu, Jia Huang, Mengguo Liu, Zhuoya Xu, Yanyun Ma, Mengkun Shi, Jiucun Wang and Wenyu Wu
    Citation: Cell Communication and Signaling 2025 23:141
    Content type: Research Published on:

  45. A dysregulated inflammatory response and inflammation-associated cell death are central features of renal ischemia-reperfusion injury (IRI). PANoptosis, is a recently recognized form of inflammatory programmed...

    Authors: Shaoyong Zhuang, Fangzhou Li, Liya Wang, Zilong Lai, Dawei Li, Haoyu Wu, Jiajin Wu, Junwen Qu, Xianyun Zhang, Ming Zhang, Ruoyang Chen and Xiaodong Yuan
    Citation: Cell Communication and Signaling 2025 23:140
    Content type: Research Published on:

  46. Caveolin-1 (CAV1) is a membrane protein that promotes migration, invasion and metastasis of cancer cells when phosphorylated on tyrosine-14 (Y14) by a cell intrinsic mechanism involving the activation of a nov...

    Authors: R. Huilcaman, A. Campos, P. Contreras, L. Simón, M. Varas-Godoy, F. Grünenwald, Baohai Shao, Jay Heinecke, L. Lobos-Gonzalez, L. Leyton and A. F. G. Quest
    Citation: Cell Communication and Signaling 2025 23:139
    Content type: Research Published on:

  47. Allergic asthma is a chronic airway disease characterized by an allergic response and altered immune tolerance. CD4+ tissue-resident memory T (TRM) cells are crucial in the chronic and relapsing pathogenesis of a...

    Authors: Meng Zhang, Sheng-ce Tao, Na Li, Jingjing Feng, Tianyun Shi, Yunxia Yu, Xiaoting Ren, Jiafeng Sha, Zhoufang Mei and Zhijun Jie
    Citation: Cell Communication and Signaling 2025 23:138
    Content type: Research Published on:

  48. Limited treatment options exist for refractory ovarian cancer (OC) due to its poor response to immune therapies. Therefore, there is an urgent need to develop new effective treatment strategies. Chicoric acid ...

    Authors: Hongwei Lan, Jingjuan Zhu, Helei Hou, Chuantao Zhang, Xingfa Huo, Yuming Zhang, Fangfang Yang, Na Zhou and Xiaochun Zhang
    Citation: Cell Communication and Signaling 2025 23:137
    Content type: Research Published on:

  49. High expression of basal cell adhesion molecule (BCAM) is a hallmark of ovarian cancer (OC) progression. BCAM facilitates transcoelomic dissemination by promoting mesothelial cell clearance at peritoneal attac...

    Authors: Suresh Sivakumar, Sonja Lieber, Raimund Dietze, Vanessa M. Beutgen, Eileen C. Sutor, Sophie Heidemann, Florian Finkernagel, Julia Teply-Szymanski, Andrea Nist, Thorsten Stiewe, Katrin Roth, Silke Reinartz, Johannes Graumann, Sabine Müller-Brüsselbach and Rolf Müller
    Citation: Cell Communication and Signaling 2025 23:136
    Content type: Research Published on:

  50. The P21 activated kinases (PAK) are frequently dysregulated in cancer and have central roles in oncogenic signalling, prompting the development of PAK inhibitors (PAKi) as anticancer agents. However, such comp...

    Authors: Pedro Casado, Santiago Marfa, Marym M. Hadi, Henry Gerdes, Sandra M. Martin-Guerrero, Farideh Miraki-Moud, Vinothini Rajeeve and Pedro R. Cutillas
    Citation: Cell Communication and Signaling 2025 23:135
    Content type: Research Published on:
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  • Citation Impact 2023
    Journal Impact Factor: 8.2
    5-year Journal Impact Factor: 8.0
    Source Normalized Impact per Paper (SNIP): 1.569
    SCImago Journal Rank (SJR): 2.308

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Cell Communication and Signaling

ISSN: 1478-811X